Dopamine receptor D1

DRD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OZ5
Identifiers
Aliases	DRD1, dopamine receptor D1, DADR, DRD1A
External IDs	OMIM: 126449 MGI: 99578 HomoloGene: 30992 GeneCards: DRD1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 175,440,036 bp[1] End 175,444,182 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 28.4 cM Start 54,205,202 bp[2] End 54,209,724 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus nucleus accumbens putamen prefrontal cortex Brodmann area 9 cingulate gyrus Brodmann area 46 amygdala orbitofrontal cortex middle frontal gyrus Top expressed in nucleus accumbens olfactory tubercle globus pallidus superior frontal gyrus temporal lobe amygdala urethra suprachiasmatic nucleus piriform cortex prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function dopamine neurotransmitter receptor activity dopamine binding protein binding dopamine neurotransmitter receptor activity, coupled via Gs G protein-coupled receptor activity signal transducer activity G-protein alpha-subunit binding Cellular component membrane nucleus endoplasmic reticulum integral component of membrane plasma membrane endoplasmic reticulum membrane integral component of plasma membrane ciliary membrane endomembrane system non-motile cilium glutamatergic synapse GABA-ergic synapse integral component of postsynaptic membrane integral component of presynaptic membrane dendritic spine dendrite cell projection cilium Biological process positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway muscle contraction protein import into nucleus positive regulation of potassium ion transport response to amphetamine learning feeding behavior long-term depression temperature homeostasis striatum development prepulse inhibition response to cocaine grooming behavior behavioral response to cocaine locomotory behavior dentate gyrus development transmission of nerve impulse memory positive regulation of synaptic transmission, glutamatergic synapse assembly habituation adult walking behavior peristalsis cellular response to catecholamine stimulus adenylate cyclase-activating dopamine receptor signaling pathway regulation of dopamine uptake involved in synaptic transmission associative learning astrocyte development G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger positive regulation of release of sequestered calcium ion into cytosol mating behavior behavioral fear response activation of adenylate cyclase activity dopamine receptor signaling pathway conditioned taste aversion cerebral cortex GABAergic interneuron migration glucose import visual learning sensitization positive regulation of cell migration operant conditioning vasodilation regulation of dopamine metabolic process dopamine metabolic process phospholipase C-activating dopamine receptor signaling pathway maternal behavior dopamine transport hippocampus development neuronal action potential long-term potentiation signal transduction synaptic transmission, dopaminergic positive regulation of gene expression cellular response to dopamine regulation of protein phosphorylation G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1812 13488 Ensembl ENSG00000184845 ENSMUSG00000021478 UniProt P21728 Q61616 RefSeq (mRNA) NM_000794 NM_001291801 NM_010076 RefSeq (protein) NP_000785 NP_001278730 NP_034206 Location (UCSC) Chr 5: 175.44 – 175.44 Mb Chr 13: 54.21 – 54.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dopamine receptor D₁, also known as DRD1. It is one of the two types of D₁-like receptor family — receptors D₁ and D₅. It is a protein that in humans is encoded by the DRD1 gene.^[5][6][7][8]